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SUMMARY:Large scale genomic analyses of complex traits in human population
 s. - Dr Nicole Soranzo\, Wellcome Trust Sanger Institute\, Genome Campus\,
  Hinxton
DTSTART:20141120T143000Z
DTEND:20141120T153000Z
UID:TALK54026@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:My group works on understanding the effect of genetic determin
 ants of variation in complex traits in healthy human populations. In my ta
 lk I will first present general principles and advances in unravelling the
  genetic architecture of complex\, and our efforts to advance understandin
 g on the role of rare variation through whole-genome sequencing studies. I
  will then focus on our work in haematopoiesis\, or the formation of blood
  cellular elements\, which represents a paradigm of stem cell biology and 
 development.I will discuss efforts to discover and characterize the conseq
 uences of genetic variation in human blood cells. I will then describe ong
 oing work in my team to correlate genetic variation in human healthy popul
 ations with variation in cellular and molecular traits including gene expr
 ession through RNA sequencing and methylation data. Among the data present
 ed\, are initial results from the BLUEPRINT project (http://www.blueprint-
 epigenome.eu/)\, which is generating deep genetic\, transcriptomic and epi
 genetic maps of several human blood elements. 
LOCATION:Part II Room\, Department of Genetics
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