BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Evolution and dynamics of transcription factor repertoires - Sarah
  Teichmann (LMB)
DTSTART:20061025T130000Z
DTEND:20061025T140000Z
UID:TALK5404@talks.cam.ac.uk
CONTACT:Stephen Eglen
DESCRIPTION:Regulation of gene expression influences almost all biological
 \nprocesses in an organism\, and sequence-specific DNA-binding\ntranscript
 ion factors are critical to this control. These\ntranscription factors are
  involved in complex circuits of regulation\nbetween transcription factors
  and target genes (Babu et al.\,\n2004). Transcription factors that bind s
 pecific DNA sequences are\narguably the core information-carrying molecule
 s in regulatory\nnetworks\, and are therefore of particular interest in un
 derstanding\nthe evolution of organismal complexity.\n\nHowever\, for most
  genomes\, the repertoire of transcription factors is\nonly partially know
 n.  To fill this void\, we have developed a novel\ntranscription factor id
 entification method\, providing genome-wide\ntranscription factor predicti
 ons for organisms from across the tree of\nlife\, available at www.transcr
 iptionfactor.org (Kummerfeld &\nTeichmann\, 2006).\n\nBy integrating annot
 ated transcription factors with expression data\,\nwe have started to gain
  insight into the dynamics of transcription\nfactor expression under diffe
 rent cellular conditions in a unicellular\norganism (Luscombe et al\,. 200
 4) and in different developmental stages\nand tissues in a multi-cellular 
 organism. Both analyses reveal the\nimportance of combinatorial action of 
 transcription factors to\ndetermine the state of a cell\, and the role of 
 ubiquitous\ntranscription factor hubs.
LOCATION:MR5\, DAMTP
END:VEVENT
END:VCALENDAR