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SUMMARY:Plenary Lecture 4: Phage and Origins of the Immune System - Rohwer
 \, F (San Diego State University)
DTSTART:20140910T144500Z
DTEND:20140910T152000Z
UID:TALK54124@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Immune responses and mucosal surfaces of corals and humans are
  strikingly similar despite greater than 500 million years of divergence. 
 Here we show that humans and phage both use bacteriophage to protect again
 st bacteria and establish microbiomes. This Bacteriophage Adherence to Muc
 us (BAM) model is applicable to all metazoans. The model links hypervariab
 le phage capsid decoration proteins with the adherence of phage to mucus a
 nd it's consequent reduced bacterial pathogenesis of underlying host epith
 elium. The relationships delineated make the world's most abundant biologi
 cal entities central to the metazoan immune system. In so doing\, they adv
 ance our understanding of immunology and the microbial ecology of a key me
 tazoan-associated environments\, and will open new directions in immunolog
 ical engineering.\n
LOCATION:Seminar Room 1\, Newton Institute
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