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SUMMARY:CVD Forum: Transcriptional variation in human induced pluripotent 
 stem cells (iPSCs) and their derivatives - Dr Daniel Gaffney\, Wellcome Tr
 ust Sanger Institute
DTSTART:20141008T130000Z
DTEND:20141008T140000Z
UID:TALK54151@talks.cam.ac.uk
CONTACT:38510
DESCRIPTION:*About the speaker:* Daniel earned his PhD in evolutionary gen
 etics from Edinburgh University in 2006 under the supervision of Dr Peter 
 Keightley. His graduate research used computational methods to study varia
 tion in the mutation rate and natural selection in noncoding DNA. From 200
 6 to 2008 he pursued a postdoc with Dr Jacek Majewski in McGill University
  and Genome Quebec Genome Centre\, where he worked on the evolution of tra
 nscriptional regulation in primates\, and the role of alternative splicing
  in embryonic development. From 2008 until 2011 he worked on population ge
 netic variation in gene expression and regulation with Dr Jonathan Pritcha
 rd at the University of Chicago.\n\nIn July 2011 Daniel started as a Caree
 r Development Fellowship Group Leader at the Wellcome Trust Sanger Institu
 te. The long-term goal of the group is to understand how changes in gene r
 egulation play a role in disease susceptibility and human evolution. His r
 esearch combines statistical genetics and comparative genomics with high-t
 hroughput experimental techniques\, such as ChIP-seq and DNaseI-seq\, in h
 uman cells to address these questions. The group uses naturally occurring 
 human genetic variation as a model system to test hypotheses about gene re
 gulation. The team is also interested in developing evolutionary models of
  gene regulation to understand how changes at the molecular level drive ge
 ne expression divergence between species.
LOCATION:New Seminar Rooms\, Strangeways Research Laboratory
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