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SUMMARY:Plenary Lecture 6: Mixed and Hierarchical Utilization of Carbon Su
 bstrates by Bacteria - Hwa\, T (University of California\, San Diego)
DTSTART:20140911T083000Z
DTEND:20140911T090500Z
UID:TALK54155@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Co-authors: Hiroyuki Okano (UC San Diego)\, Rutger Hermsen (Ut
 recht University)\, Conghui You (UC San Diego)\n\nWhen bacteria are cultur
 ed in medium with multiple carbon substrates\, some substrate combinations
  are consumed simultaneously while other combinations are consumed sequent
 ially. Understanding and manipulating the order of carbon utilization is c
 rucial in characterizing trophism in complex ecosystems such as the gut mi
 crobiota\, and in optimizing synthetic biology applications such as the br
 eakdown of cellulose for biofuel production. Building on recent advances i
 n the understanding of metabolic coordination exhibited by Escherichia col
 i cells through cAMP-Crp signaling\, we show that this signaling system al
 one gives rise to simultaneous utilization\, and derive an algebraic formu
 la describing the resulting growth rate\, based only on the growth rates o
 n individual substrates. For substrate combinations that are utilized hier
 archically\, we reveal a simple regulatory strategy by which the hierarchy
  is ordered roughly by the rate of growth on single substrates. \n
LOCATION:Seminar Room 1\, Newton Institute
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