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SUMMARY:Plenary Lecture 10: Phylogeny and functionality in anaerobic micro
 bial communities: making sense of metabolite outputs and population dynami
 cs - Flint\, H (University of Aberdeen)
DTSTART:20140911T130000Z
DTEND:20140911T133500Z
UID:TALK54163@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Regions of the mammalian gut harbour dense microbial communiti
 es that derive most of their energy from the anaerobic breakdown of dietar
 y carbohydrates that are not digested by host enzymes. Especially in herbi
 vores\, the organic acids produced by microbial fermentation in turn provi
 de a major supply of energy for the host\, while in the human colon they h
 ave an important impact on health. It is of key interest therefore to unde
 rstand how the microbial communities of the rumen and human large intestin
 e respond to dietary change and how this affects the production of alterna
 tive metabolic products. While some metabolic and degradative capabilities
  are widespread among the microbiota\, many (eg. methanogenesis\, degradat
 ion of crystalline cellulose\, lactate utilization) appear to be restricte
 d to a small number of phylogenetic groups. Information from cultured isol
 ates\, defined consortia\, experimental models\, metagenomics and in vivo 
 studies is helping to define functional group s of human gut bacteria whos
 e characteristics can be incorporated into theoretical models that explore
  inter-group interactions and community responses.\n
LOCATION:Seminar Room 1\, Newton Institute
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