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SUMMARY:Contributed Talk 3: A functional population model of fiber degrada
 tion by the human intestinal microbiota - Laroche\, BA (INRA - Institut Na
 tional de la Recherche Agronomique)
DTSTART:20140911T141000Z
DTEND:20140911T142500Z
UID:TALK54166@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Co-authors: Marion LECLERC (MICALIS\,INRA)\, Sebastien RAGUIDE
 AU (MIA-J\, INRA) \n\nThe human intestinal microbiota is a complex microbi
 al ecosystem that plays a crucial role in several aspects of human health.
  It is particularly involved in the metabolism of residual fibres\, throug
 h anaerobic digestion\, thus providing significant energy (Short Chain Fat
 ty Acids\, simple sugars) and vitamins to the host. This ecosystem remains
  largely unexplored as a result of its limited accessibility and its compl
 exity. We will present the ongoing development of an in silico model of th
 e ecosystem\, in interaction with its environment and its host. Our aim is
  to provide a virtual platform for knowledge and data integration\, and si
 mulation. A focus will be made on the structuration of the ecosystem into 
 functional populations. We show how Whole Genome Sequencing (WGS) data fro
 m metagenomic analyses can be used to analyse the structure of carbohydrat
 es degradation-related functions. These data give an insight of the gene c
 ontent of an entire microbial community\, even if the organisms that compo
 se it cannot be cultivated. In addition to the potential of conventional m
 olecular inventory techniques (such as targeting ADNr16s)\, which allows a
 n analysis of diversity\, WGS approaches provide an access to the function
 s. We show how the information obtained can be integrated in the model and
  discuss the underlying modelling hypotheses. \n
LOCATION:Seminar Room 1\, Newton Institute
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