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SUMMARY:High resolution models of genome regulatory events - Prof. David G
 ifford (MIT)
DTSTART:20061009T153000Z
DTEND:20061009T163000Z
UID:TALK5418@talks.cam.ac.uk
CONTACT:Gos Micklem
DESCRIPTION:David's group has had a long-standing collaboration with Rick 
 Young's lab at the Whitehead Institute and this has resulted in many semin
 al papers.\n\n\nAbstract:\n\nUnderstanding how transcription factors and c
 hromatin modifiers regulate gene expression is a central problem in biolog
 y.  A new computational approach\, Joint Binding Deconvolution\, permits t
 he location of protein-genome binding events to be determined at high spat
 ial resolution from chromatin immunoprecipitation experiments (ChIP-Chip).
  We have combined ChIP-Chip data with expression data and genome sequence 
 to reveal regulatory networks in yeast and components of the core\nnetwork
  that regulates pluripotency in human embryonic stem cells.\n
LOCATION:MR2\, DAMTP
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