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SUMMARY:What can we understand from the structure of a protein? - Dr Paul 
 Elliott\, Laboratory of Molecular Biology\, Medical Research Centre
DTSTART:20141120T131000Z
DTEND:20141120T140000Z
UID:TALK54449@talks.cam.ac.uk
CONTACT:Felice Torrisi
DESCRIPTION:Investigating how proteins/enzymes interact and function is ce
 ntral to our understanding of cellular processes that are all too often de
 fective in human diseases. Structural biology allows us to analyse these i
 nteractions\, sometimes at atomic resolution\, and to dissect complicated 
 biological processes. Our experimentally derived models serve as a platfor
 m from predicting drug-binding sites to understanding key mutations that d
 isrupt an important biological pathway. The term "structural biology" repr
 esents many complementary and technically challenging techniques\, which o
 ften requires critical analysis of our models and requires further biochem
 ical and biophysical techniques for validation. I shall discuss what we ca
 n learn with these models in the context of my research into understanding
  how post-translational modification of proteins by a small protein\, ubiq
 uitin\, is an important signal during the inflammatory response.
LOCATION:1 Newnham Terrace\, Darwin College
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