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SUMMARY:Evolving technologies for liver targeted gene and cell therapies. 
 - Professor Ian Alexander\, Professor in Paediatrics &amp\; Molecular Medi
 cine\, Disciplines of Paediatrics and Child Health and Genetic Medicine\, 
 The Children's Hospital at Westmead\, 
DTSTART:20141008T151500Z
DTEND:20141008T161500Z
UID:TALK54464@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Genetic and acquired diseases of the liver are collectively pr
 evalent and remain challenging to treat\, with the most severe phenotypes 
 necessitating liver transplantation for long term survival. Evolving thera
 peutic modalities\, such as liver targeted gene and cell therapy\, are the
 refore of immense research interest\, and are show exciting early therapeu
 tic promise. This seminar will explore the rapidly developing technologies
  available for genetic manipulation of the liver\, taking into account the
  liver’s unique biology and disease-specific requirements for therapeuti
 c effect. The convergence of gene and cell therapy will also be examined\,
  in particular strategies for selective in vivo expansion of therapeutic h
 epatocyte sub-populations. This in turn opens the prospect of curing genet
 ic liver disease by targeted genome editing rather than by contemporary ge
 ne addition strategies 
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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