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SUMMARY:Study and characterization of MET1 homologues in Arabidopsis thali
 ana - Christophe Buser\, Sainsbury Lab
DTSTART:20141212T090000Z
DTEND:20141212T093000Z
UID:TALK54589@talks.cam.ac.uk
CONTACT:38889
DESCRIPTION:1st year graduate talk\n\nEpigenetic marks are of high importa
 nce for gene regulation. The most studied epigenetic mark is DNA methylati
 on that is mainly associated with gene silencing in plant and mammals. Ara
 bidopsis thaliana mutants in the gene encoding the main methyltransferase 
 (MET1) show global hypomethylation and ectopic expression of genes and tra
 nsposable elements\, leading to serious phenotypic consequences. DNA of me
 t1 mutants loses almost all of their CG methylation and this effect cannot
  be reverted by reintroducing wild-type version of MET1 gene. The function
 s of MET1 homologues MET 2\, MET3 and MET4 are still unknown to this date 
 but have been hypothesized to influence endosperm imprinting. In my resear
 ch\, I propose to characterise phenotypes and DNA methylation levels of th
 e combinations of mutants of MET1 homologues in Arabidopsis thaliana to un
 veil their functions.
LOCATION:Department of Plant Sciences\, Large Lecture Theatre
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