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SUMMARY:Cortical phase\, amplitude\, and cross-frequency interactions duri
 ng task performance and rest. - Matias Palva\, Neuroscience Center\, Unive
 rsity of Helsinki\, Finland
DTSTART:20140930T100000Z
DTEND:20140930T110000Z
UID:TALK54878@talks.cam.ac.uk
CONTACT:Mikail Rubinov
DESCRIPTION:Mapping the anatomical patterns\, topology\, and dynamics of c
 ortical connectivity\, both functional and structural\, is central for elu
 cidating the systems-level mechanisms governing brain dynamics in vivo. Co
 mplementing the large body of studies using MRI-based fMRI and DTI/DSI map
 s of functional and structural connectivity\, respectively\, several appro
 aches have recently been presented for using MEG and EEG in the electrophy
 siological mapping of cortical connectivity. In my presentation\, I will d
 iscuss our pipeline for MEG/EEG-source-reconstruction based interaction ma
 pping as well as both the commonly and the more rarely acknowledged pitfal
 ls in the identification of phase and amplitude correlations in electrophy
 siological data.\n\nThe phenomenology and functional significance of oscil
 latory coupling can be addressed both with resting-state analyses and cogn
 itive paradigms. I will present our recent MEG and SEEG observations linki
 ng transient brain dynamics with the traditional connectivity estimates. W
 e have also used MEG to map the networks of within- and cross-frequency ph
 ase synchrony observed during visual working memory retention. These phase
  interactions are memory load dependent and behaviorally significant\, and
  may hence yield insight both into the neuronal substrates of working memo
 ry and into the mechanisms bridging neuronal processing taking place concu
 rrently in multiple frequency bands. Overall\, these data emphasize both t
 he putative functional significance of the interactions among cortical osc
 illations and that several technical challenges must be overcome to fully 
 utilize the potential of electrophysiological methods in the study of the 
 human connectome.\n
LOCATION:MRC CBU lecture theatre\, 15 Chaucer Road
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