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SUMMARY:Enhancing single-molecule detection with DNA origami nanostructure
 s - Prof. Dr. Philip Tinnefeld\, Institut für Physikalische &amp\; Theore
 tische Chemie TU Braunschweig
DTSTART:20141107T140000Z
DTEND:20141107T150000Z
UID:TALK55266@talks.cam.ac.uk
CONTACT:Dr Eileen Nugent
DESCRIPTION:In recent years\, we have combined DNA nanotechnology with sin
 gle-molecule\nfluorescence to create functional single-molecule devices su
 ch as nanoscopic\nrulers for superresolution microscopy and energy transfe
 r switches1-4. DNA\norigamis are also used to improve single-molecule dete
 ction by fluorescence\nenhancement with nanoantennas or by single-molecule
  placement in zeromode\nwaveguides using nanoadapters5\, 6. Especially\, f
 luorescence enhancement with\nself-assembled nanoparticles holds great pot
 ential for single-molecule\ndetection at higher concentrations but also fo
 r diagnostic applications7. We\nwill discuss recent advancement in fluores
 cence enhancement and how to\ndisentangle the complex factors that influen
 ce the fluorescence of single\nmolecules near metallic nanostructures8\, 9
 . 
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
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