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SUMMARY: Simulation Approaches to Biomolecular Recognition and Assembly  -
  Dr Peter J Bond\, Bioinformatics Institute (BII) A*STAR\, Singapore.
DTSTART:20141203T140000Z
DTEND:20141203T150000Z
UID:TALK55329@talks.cam.ac.uk
CONTACT:38916
DESCRIPTION:Recognition and assembly processes are key to the mechanisms o
 f action of a range of biomolecules\, spanning functions such as folding\,
  signalling\, and transport. Many of the macromolecules associated with su
 ch processes represent important targets for pharmaceutical intervention\,
  and offer potential benefits for manipulation in bionanotechnology. Molec
 ular simulations provide a theoretical means to study these biomolecules o
 n time and length scales inaccessible by other methods. This can yield bot
 h visual and quantitative insights into their dynamics and thermodynamics\
 , and provide information complementary to experimental data. Here\, I wil
 l provide an overview of our group's simulation and modelling studies used
  to understand biomolecular recognition and assembly. These include the us
 e of simplified models to study the spontaneous assembly of proteins withi
 n biomembranes\, as well as large-scale\, atomically detailed simulations 
 to unravel the link between ligand recognition and downstream signalling i
 n immune receptor complexes. This is providing novel mechanistic insights 
 and potential routes to therapeutic targeting of conditions ranging from i
 nflammatory disorders to obesity.
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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