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SUMMARY:Collective Cell Migration: A Cellular\, Molecular &amp\; Modelling
  Approach - Professor Roberto Mayor\, UCL\, Department of Cell and Develop
 mental Biology
DTSTART:20141030T160000Z
DTEND:20141030T170000Z
UID:TALK55457@talks.cam.ac.uk
CONTACT:16026
DESCRIPTION:**Abstract**\n\nCollective cell migration is a common behaviou
 r observed during normal embryonic development and in pathological conditi
 ons\, such as cancer metastasis.  It corresponds to the coordinated migrat
 ion of tens or hundreds of cells and has been shown to be more efficient t
 hat single cell migration.  How this higher efficiency is achieved and the
  collective behaviour is maintained remains unknown.  We have used the mig
 ration of neural crest cells\, a transient embryonic cell population\, to 
 study the biological basis of collective cell migration.  Our data show th
 at a balance between cell-cell attraction and cell-cell repulsion is essen
 tial for directional collective cell migration.  \n\nHere\, I will present
  a parameterized discrete element model of neural crest cells\, to investi
 gate how these mechanisms contribute to long-range directional migration. 
 Several predictions of the model are experimentally tested. We conclude th
 at directional migration is an emergent property and does not require acti
 on of external signals.\n\n=======\n\n**More About the Speaker**\n\nRobert
 o Mayor is a Professor of Developmental and Cellular Neurobiology at Unive
 rsity College London\, UK. He was named International Scholar of the Howar
 d Hughes Medical Institute (HHMI). He is a member of the editorial board o
 f Development\, Developmental Biology\, Mechanisms of Development\, Develo
 pmental Dynamics\,  etc.\;  and Associate Editor of BMC Developmental Biol
 ogy and the International Journal of Developmental Biology. He was founder
  and president of the Latin American Society of Developmental Biology (LAS
 DB). The primary aim of his research group is to elucidate the mechanism t
 hat underlies the development of the Neural Crest. He would like to know h
 ow Neural Crest cells acquire their identity within the ectoderm and how t
 heir migration and differentiation is controlled.  Mayor’s lab has devel
 oped a multidisciplinary approach\, using techniques and tools from cell a
 nd developmental biology\, together with techniques from physics and mathe
 matics. \n\nhttp://www.ucl.ac.uk/cdb/research/mayor\n\nhttp://www.ucl.ac.u
 k/cdb/research/mayor/mayor_lab\n\nhttp://biodesarrollo.unab.cl/
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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