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SUMMARY:Prospects and Obstacles affecting Cell Replacement in Humans - Pro
 f. Sir John Gurdon\, Dept. Zoology\, University of Cambridge
DTSTART:20141215T192500Z
DTEND:20141215T210000Z
UID:TALK55532@talks.cam.ac.uk
CONTACT:Dr Nigel Bennee
DESCRIPTION: The early results of nuclear transplantation in animals will 
 be described.  These show that nearly all cells have a complete genome an
 d therefore that\, in principle\, the nucleus of one kind of specialized c
 ell can be used to generate all other kinds of cells.  Over time\, somati
 c cell nuclear transfer was achieved in mammals and most recently in human
 s.  \n Induced pluripotency can now be achieved by incubating somatic cel
 ls in a selection of transcription factors.  This method has the great ad
 vantage of making nuclear reprogramming possible without the use of eggs\,
  but it is very inefficient and can lead to defects in reprogrammed cells 
 as they are grown in the laboratory.  This leads to the desire to underst
 and the mechanism of nuclear reprogramming by eggs\, which have a natural 
 ability toreprogram the highly specialized sperm cell.\n Current knowledge
  about the mechanism of reprogramming by eggs will be discussed.\n\nThe ta
 lk will discuss the current level of success in cell replacement in humans
 .  It will also discuss the ethical and legal constraints in bringing thi
 s new technology into general use for patients.\n
LOCATION:Wolfson Lecture Theatre\, Churchill College\, Storey's Way\, Camb
 ridge
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