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SUMMARY:Tools for refinement against low resolution X-ray data and fit to 
 EM reconstructions - Dr Garib Murshudov\, LMB\, MRC
DTSTART:20141203T110000Z
DTEND:20141203T120000Z
UID:TALK55583@talks.cam.ac.uk
CONTACT:23791
DESCRIPTION:Abstract:\n\nAccurate model building and refinement is one of 
 the main components of X-ray crystal structure analysis and fit into singl
 e particle high resolution cryo-EM reconstructions. We have have developed
  several tools to increase reliability of models derived from low resoluti
 on refinement against X-ray crystallographic data and cryo-EM maps.These i
 nclude using known crystal structures\, information about secondary struct
 ures\, RNA/DNA base pairing and base stacking interactions. We have also i
 mplemented reciprocal space version of real-space refinement against elect
 ron density and potential maps. \nIn this talk a new software designed for
  designing accurate ligand description - ACEDRG that is based on extracted
  and organised information from the Crystallographic Open Database (COD) w
 ill also be described.\n\n
LOCATION:Biochemistry Lecture Theatre\, Sanger Building\, Tennis Court Roa
 d
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