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SUMMARY:Contributed Talk 1: The Crabtree effect and its influences on fitn
 ess of yeast populations from natural isolates - Cunnington\, E (Massey Un
 iversity)
DTSTART:20141027T143000Z
DTEND:20141027T144500Z
UID:TALK55697@talks.cam.ac.uk
CONTACT:Mustapha Amrani
DESCRIPTION:Co-author: Thomas Pfeiffer (Massey University) \n\nYeasts degr
 ade sugars in order to produce ATP. Two metabolic pathways are distinguish
 ed in ATP production: respiration and fermentation. While the respiration 
 pathway occurs in presence of oxygen and produces up to 38 ATP to the cell
 \, fermentation does not require oxygen but is also much less efficient (2
  ATP produced by sugar converted into ethanol). Despite the low efficiency
  of fermentation\, a certain number of yeasts species (including the brewe
 rs yeast Saccharomyces cerevisiae) have the ability to ferment sugar in ae
 robic conditions\, this in addition to the respiration pathway when sugar 
 concentration is sufficiently high. This is known as the Crabtree effect. 
 It remains unclear why certain yeasts exhibit an aerobic alcoholic ferment
 ation\, and one explanation to this phenomenon relies on the increase in A
 TP production rate\, which come at the cost of the production yield. This 
 explanation is supported by the yield/rate trade-off theory. However this 
 theory has not yet been conclusively supported by experiments. In my talk\
 , I will introduce novel experimental approaches that might be used to inv
 estigate the yield/rate trade-off theory under the Crabtree effect in yeas
 t from natural isolates.\n
LOCATION:Seminar Room 1\, Newton Institute
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