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SUMMARY:Transcriptional Network Control of Blood Cell Development - Profes
 sor Bertie Göttgens\, Department of Haematology
DTSTART:20150225T140000Z
DTEND:20150225T150000Z
UID:TALK55788@talks.cam.ac.uk
CONTACT:38916
DESCRIPTION:Haematopoiesis represents one of the most tractable models of 
 organ development and cellular differentiation. Transcription factor (TF) 
 proteins have long been recognized as major regulators of blood cell devel
 opment as well as the subsequent differentiation into the multiple mature 
 haematopoietic lineages.  It remains largely unknown however\, how individ
 ual TFs are integrated into wider transcriptional regulatory networks\, an
 d how combinatorial TF interactions within these networks drive lineage sp
 ecific gene expression programs.  We have used single cell expression anal
 ysis to capture cells with blood-forming potential at four sequential deve
 lopmental stages. Using novel computational approaches\, we have reconstru
 cted the developmental journey at single cell resolution\, which reveals a
 synchrony of maturation and sequential waves of expression for major regul
 ators.  We have then used the single cell expression data to construct a t
 ranscriptional regulatory network model\, and used mouse embryos and embry
 onic stem cells to validate several model predictions. Our work therefore 
 demonstrates that single cell analysis of a developing organ coupled with 
 novel computational approaches can reveal the transcriptional programs tha
 t control organogenesis. 
LOCATION:MR4\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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