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SUMMARY:The Annual Adrian Lecture. &quot\;The flow of information underlyi
 ng a tactile decision.&quot\; - Dr Karel Svoboda. Janelia Farm\, USA.
DTSTART:20141201T163000Z
DTEND:20141201T180000Z
UID:TALK55799@talks.cam.ac.uk
CONTACT:P.H. Marchington
DESCRIPTION:Abstract\nPerceptual decisions involve distributed cortical ac
 tivity. Does information flow sequentially from one cortical area to anoth
 er\, or do networks of interconnected areas contribute at the same time? H
 ere we delineate when and how activity in specific areas drives a whisker-
 based decision in mice. A short-term memory component temporally separated
  tactile "sensation" and "action" (licking). Using optogenetic inhibition 
 (spatial resolution\, 2 mm\; temporal resolution\, 100 ms)\, we surveyed t
 he neocortex for regions driving behavior during specific behavioral epoch
 s. Barrel cortex was critical for sensation. During the short-term memory\
 , unilateral inhibition of anterior lateral motor cortex biased responses 
 to the ipsilateral side. Consistently\, barrel cortex showed stimulus-spec
 ific activity during sensation\, whereas motor cortex showed choice-specif
 ic preparatory activity and movement-related activity\, consistent with ro
 les in motor planning and movement. These results suggest serial informati
 on flow from sensory to motor areas during perceptual decision making.\n
LOCATION:The Physiology Main Lecture Theatre\, Department of Physiology De
 velopment and Neuroscience
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