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SUMMARY:Signals and Factors Controlling Stem Cell Activity in the Adult Br
 ain - Dr François Guillemot\, MRC National Institute for Medical Research
 \, Mill Hill\, London
DTSTART:20150226T160000Z
DTEND:20150226T170000Z
UID:TALK56005@talks.cam.ac.uk
CONTACT:16026
DESCRIPTION:	Neural stem cells can adopt diverse fates\, including quiesce
 nce\, self-renewal and neuronal or glial differentiation. The selection of
  appropriate stem cell fates is crucial for the normal growth of the embry
 onic brain and for the functional integrity of the mature brain. \n	\nThe 
 control of neural stem cells fates by extracellular signals has been thoro
 ughly investigated. In contrast\, little is known of the transcription fac
 tors that mediate the activity of these extrinsic signals and implement ap
 propriate fate decisions.  \n\nUsing high throughput genomic analysis and 
 genetic approaches in neural stem cell cultures and in the embryonic and a
 dult mouse brain in vivo\, we have identified two transcription factors\, 
 ASCL1 and NFIX\, which respectively promote neural stem cell activity and 
 neural stem cell quiescence in the adult brain and in stem cell culture. W
 e are currently investigating the regulation of the activity of these fact
 ors and the nature of the gene expression programmes that they activate.\n
 \n\nSpeaker website:\nhttp://www.nimr.mrc.ac.uk/research/francois-guillemo
 t/
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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