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SUMMARY:Mechanisms of Hypoxic Pulmonary Vasoconstriction - Professor Norbe
 rt Weissmann\, ECCPS Professur\, University of Giessen\, Germany
DTSTART:20150305T160000Z
DTEND:20150305T170000Z
UID:TALK56007@talks.cam.ac.uk
CONTACT:16026
DESCRIPTION:Hypoxic pulmonary vasoconstriction (HPV) is an essential mecha
 nism of the lung which matches blood perfusion to alveolar ventilation. Un
 der conditions of regional alveolar hypoxia\, HPV reduces blood flow to po
 orly ventilated and thus hypoxic lung regions\, thereby optimising gas exc
 hange. HPV can also be termed "normoxic pulmonary vasodilatation"\, as HPV
  is activated after birth when alveolar ventilation is initiated. Disturba
 nces in vasorelaxation after birth may contribute to development of persis
 tent pulmonary hypertension of the newborn (PPHN).\n\nHPV's underlying mec
 hanisms have not been fully elucidated yet. At the level of oxygen sensors
 \, reactive oxygen species (ROS)-producing systems like mitochondria and N
 ADPH oxidases have been proposed\, with some controversy. Voltage-dependen
 t potassium channels (Kv-channels) and transient receptor potential channe
 ls (TRPC) have also been shown to be essential.\n\nA better understanding 
 of these would allow us to treat dysregulated HPV\, the resulting hypoxaem
 ia and also PPHN. \n\nSpeaker website:\nhttp://www.ukgm.de/ugm_2/deu/ugi_p
 ne/ugi_pne_team.php?id=1251
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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