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SUMMARY:Boron based dynamic bonding: an emerging construction tool for Che
 mical Biology - Professor Pedro Gois\, Lisbon University
DTSTART:20141119T160000Z
DTEND:20141119T170000Z
UID:TALK56153@talks.cam.ac.uk
CONTACT:Alice Wood
DESCRIPTION:Recent appreciation for the unique Boron-Nitrogen bond propert
 ies triggered a burgeoning interest for this motif. B-N bonds have been ex
 tensively exploited to construct self-assembled molecularly defined nanost
 ructures\, polymeric materials and sensors. Recently\, the isosterism betw
 een B-N and C-C bonds was also recognized as a powerful tool to tune the p
 roperties of organic molecules. In this communication\, will be presented 
 the use of this bonding motif to create useful heterocyclic compounds with
  natural-product like structures and to efficiently modify proteins promot
 ing the assemblage of therapeutically useful conjugates. \n\nKey publicati
 ons for this presentation:\n\n1.	"Targeting Cancer Cells with Folic Acid-I
 minoboronate Fluorescent Conjugates” P. M. S. D. Cal\, R. F. M. Frade\, 
 V. Chudasama\, C. Cordeiro\, S. Caddick\, P. M. P. Gois Chem. Comm. 2014\,
  50\, 5261-5263.\n2.	"Iminoboronates: A New Strategy for Reversible Protei
 n Modification" P. M. S. D. Cal\, J. B. Vicente\, E. Pires\, A. V. Coelho\
 , L. F. Veiros\, C. Cordeiro\, P. M. P. Gois J. Am. Chem. Soc. 2012\, 134\
 , 10299.\n3.	"Discovery of new heterocycles with activity against human ne
 utrophile elastase based on a boron promoted one-pot assembly reaction" F.
  Montalbano\, P. M. S. D. Cal\, M. A. B. R. Carvalho\, L. M. Gonçalves\, 
 S. D. Lucas\, R. C. Guedes\, L. F. Veiros\, R. Moreira\, P. M. P. Gois Org
 . Biomol. Chem. 2013\, 11\, 4465–4472.\n4.	“Four Component Assembly of
  Chiral N-B Heterocycles with a Natural Product Like Framework” F. Monta
 lbano\, N R. Candeias\, L. F. Veiros\, V. André\, M. T. Duarte\, M. R. Br
 onze\, R. Moreira\, P. M. P. Gois\, Org. Lett.\, 2012\, 14\, 988-991. \n
LOCATION:Wolfson Lecture Theatre\, Department of Chemistry
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