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SUMMARY:A molecular approach to the bioenergetics of sulfate reduction  - 
 Inês Cardoso Pereira\, ITQB/UNL
DTSTART:20150303T120000Z
DTEND:20150303T130000Z
UID:TALK56188@talks.cam.ac.uk
CONTACT:Alexandra Turchyn
DESCRIPTION:The dissimilation of sulfur compounds is likely to have been o
 ne of the first energy metabolisms on the early Earth [1]. However\, many 
 questions remain about how sulfur-metabolizing organisms obtain energy for
  growth from reducing\, oxidizing or disproportionating sulfur compounds. 
 In the case of sulfate reduction\, the terminal reductases involved (APS r
 eductase\, AprAB\, and dissimilatory sulfite reductase\, DsrAB) have long 
 been identified\, but how these two reactions are coupled to energy conser
 vation is still not clear. DsrAB\, in particular\, is a key enzyme in diss
 imilatory sulfur metabolism\, being present not only sulfate/thiosulfate/s
 ulfite reducing organisms\, but also in sulfur-oxidizers and sulfur dispro
 portionators. \nOur lab has studied several of the key proteins involved i
 n sulfate reduction\, including AprAB\, DsrAB and two respiratory membrane
  complexes specific to sulfur-metabolizing organisms\, QmoABC and DsrMKJOP
 \, which are involved in the electron transfer pathways with AprAB and Dsr
 AB [2]. These complexes hint at the possibility of menaquinone involvement
  and chemiosmotic energy conservation\, during sulfate reduction. In addit
 ion\, a genomic analysis of energy metabolism genes in sulfate reducers su
 ggested that the recently recognized process of electron bifurcation may a
 lso be involved [3]\, and that there are conspicuous links between sulfate
  reducers and methanogenic organisms [1].\nIn this talk I will present an 
 overview of the role of these proteins in sulfate reduction\, with a speci
 al focus on the function of the small protein DsrC as a physiological part
 ner of DsrAB and the DsrMKJOP complex [4].\n1-	Sousa\,F.L.\, Thiergart\, T
 .\, Landan\, G.\, Nelson-Sathi\,S.\, Pereira\, I.A.C.\, Allen\, J.F.\, Lan
 e\,N.\, Martin\, W. F. (2013) Early bioenergetic evolution. Phil Trans R S
 oc B\, 368\, 20130088\n2-	Grein F\, Ramos AR\, Venceslau SS\, Pereira IAC.
  (2013) Unifying concepts in anaerobic respiration: Insights from dissimil
 atory sulfur metabolism. Biochim Biophys Acta.-Bioenergetics 1827 145-160\
 n3-	Pereira IAC\, Ramos AR\, Grein F\, Marques MC\, Da Silva SM and Vences
 lau SS (2011). A comparative genomic analysis of energy metabolism in sulf
 ate reducing bacteria and archaea. Front. Microbiol. 2:69 \n4-	Venceslau S
 S\, Stockdreher Y\, Dahl C\, Pereira IAC. (2014) The “bacterial heterodi
 sulfide” DsrC is a key protein in dissimilatory sulfur metabolism\, Bioc
 him. Biophys. Acta-Bioenergetics 1837\, 1148-1164\n
LOCATION:Harker 1 seminar room\, Department of Earth Sciences
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