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SUMMARY:Finding cancer drivers in mouse\, man and dog - Dr David Adams\, E
 xperimental Cancer Genetics\, Faculty Lead Mouse Genetic Project\,  Wellco
 me Trust Sanger Institute
DTSTART:20150211T161500Z
DTEND:20150211T171500Z
UID:TALK56455@talks.cam.ac.uk
CONTACT:Fiona Roby
DESCRIPTION:Cross-species analysis of cancer genomes has contributed signi
 ficantly to our understanding of cancer evolution and the identification o
 f cancer driver genes. We have been using a combination of approaches incl
 uding genome sequencing of human and mouse tumours\, transposon screens an
 d forward genetics in the mouse\, and more recently the sequencing of dog 
 tumours to identify cancer drivers. Another aspect of our work is the use 
 of large-scale mouse genetics to find disease genes. In particular we have
  been using the stream of knockout mice generated by the Sanger Mouse Gene
 tics Project to identify host factors influencing tumour growth and metast
 atic spread. So far we have screened over 500 knockout lines identifying c
 omponents of the immune system that influence tumour growth. 
LOCATION:Lecture Theatre 2\, Department of Veterinary Medicine
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