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SUMMARY:Mitochondria-targeted Delivery Systems - Dr Shanta Dhar\, Departme
 nt of Chemistry\, University of Georgia
DTSTART:20140106T140000Z
DTEND:20140106T150000Z
UID:TALK56470@talks.cam.ac.uk
CONTACT:Alice Wood
DESCRIPTION:The potential benefits of integrating nanomaterials with prope
 rties such as biodegradability\, magnetization\, fluorescence\, and near-i
 nfrared absorption into a single object of nanoscale dimensions can lead t
 o the development of hybrid nanocarrier platforms for simultaneous targeti
 ng\, imaging\, and combination therapy administration. We are developing h
 ybrid nanoparticle (NP) systems for their potential use in organelle targe
 ting\, combination therapy of cancer\, and image-guided therapy of atherot
 hrombotic vascular diseases.\n\nMitochondrial dysfunctions cause many huma
 n disorders. A platform technology for carrying bioactive molecules to dif
 ferent mitochondrial compartments could be of enormous potential benefit i
 n medicine. We are developing rationally designed\, programmable NP platfo
 rm for diagnosis and targeted delivery of therapeutics\nfor mitochondrial 
 dysfunction related diseases. An optimized formulation for maximal mitocho
 ndrial uptake was identified through in vitro screening of a library of ch
 arge and size varied NPs and the uptake was studied by qualitative and qua
 ntitative investigations of cytosolic and mitochondrial fractions of cells
  treated with mitochondria-targeted blended NPs. The versatility of this p
 latform was demonstrated by studying a variety of mitochondria-acting ther
 apeutics for different applications. These include mitochondria targeting 
 chemotherapeutics for cancer\, mitochondrial antioxidant for disease of ce
 ntral nervous system\, and mitochondrial uncoupler for obesity. On the car
 diovascular front\, we are developing a long- circulating hybrid NP platfo
 rm to selectively target macrophages and sense apoptosis for detection of 
 plaque vulnerable to embolism.
LOCATION:Pfizer Lecture Theatre\, Department of Chemistry
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