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SUMMARY:How dynein and its co-factors at the kinetochore ensure chromosome
  segregation fidelity. - Dr Reto Gassmann\, Instituto de Biologia Molecula
 r e Celular (IBMC)\, Portugal 
DTSTART:20150219T143000Z
DTEND:20150219T153000Z
UID:TALK56515@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Accurate chromosome segregation during cell division requires 
 attachments between spindle microtubules and the kinetochore\, a multi-pro
 tein assembly that forms on each sister chromatid. The kinetochore also ha
 rbors the spindle assembly checkpoint\, a signaling network crucial for ch
 romosome segregation fidelity that detects errors in kinetochore-microtubu
 le attachments. The Rod-Zw10-Zwilch complex (RZZ) and the coiled-coil prot
 ein Spindly\, kinetochore-localized regulators of the motor cytoplasmic dy
 nein\, have essential roles in both spindle assembly checkpoint signaling 
 and kinetochore-microtubule attachment\, but the molecular underpinnings r
 emain poorly understood. We have characterized engineered point mutations 
 in RZZ subunits and Spindly using the nematode C. elegans and human cultur
 ed cells\, which has allowed us to assign specific functions to individual
  RZZ subunits and has uncovered an important role for a posttranslational 
 lipid modification in kinetochore assembly.    
LOCATION:Part II Room\, Department of Genetics
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