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SUMMARY:Computational Neuroscience Journal Club - Johannes Friedrich ( CBL
 \,  Cambridge University\, Engineering Dept.)
DTSTART:20141202T160000Z
DTEND:20141202T170000Z
UID:TALK56522@talks.cam.ac.uk
CONTACT:Guillaume Hennequin
DESCRIPTION:Johannes Friedrich will cover:\n\nEncoding and decoding in par
 ietal cortex during sensorimotor decision-making\n\nPark IM\, Meister MLR\
 , Huk AC and Pillow JW\; Nature Neuroscience 17\, 2014\n\nhttp://www.natur
 e.com/neuro/journal/v17/n10/full/nn.3800.html\n\nIt has been suggested tha
 t the lateral intraparietal area (LIP) of macaques plays a fundamental rol
 e in sensorimotor decision-making. We examined the neural code in LIP at t
 he level of individual spike trains using a statistical approach based on 
 generalized linear models. We found that LIP responses reflected a combina
 tion of temporally overlapping task- and decision-related signals. Our mod
 el accounts for the detailed statistics of LIP spike trains and accurately
  predicts spike trains from task events on single trials. Moreover\, we de
 rived an optimal decoder for heterogeneous\, multiplexed LIP responses tha
 t could be implemented in biologically plausible circuits. In contrast wit
 h interpretations of LIP as providing an instantaneous code for decision v
 ariables\, we found that optimal decoding requires integrating LIP spikes 
 over two distinct timescales. These analyses provide a detailed understand
 ing of neural representations in LIP and a framework for studying the codi
 ng of multiplexed signals in higher brain areas.
LOCATION:Engineering Department\, Baker Building (5th floor)\, MIL meeting
  room
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