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SUMMARY:Fishing for the genetic basis of skeletal evolution and disease - 
 Vahan Indjeian (MRC Clinical Sciences Centre - Imperial College London)
DTSTART:20150204T130000Z
DTEND:20150204T140000Z
UID:TALK56926@talks.cam.ac.uk
CONTACT:Marcia Kishida
DESCRIPTION:Skeletal development is a fundamental biological process that 
 has a\nmajor impact on human health\, yet the genetic mechanisms that regu
 late the formation of each and every uniquely shaped bone are largely unkn
 own. We take advantage of the dramatic skeletal differences between verteb
 rates to ask what genes regulate bone traits? What are the changes in thos
 e genes? Are the same mechanisms used when the same traits independently e
 volve in many species? Which sequence changes make our skeletons uniquely 
 human? To begin to answer these long-standing\nquestions in evolutionary b
 iology\, we use multipronged approach that combines work in two experiment
 al systems\, the threespine stickleback and mouse models\, and comparative
  genomics of humans and other vertebrates. Examples of our studies to unco
 ver the genetic basis of stickleback and human-specific skeletal traits wi
 ll be illustrated during the seminar.
LOCATION:Part II Lecture Theatre\, Department of Zoology
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