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SUMMARY:Directed Growth of CNS Tissue on Engineered and Active Surfaces fo
 r Neural Device Application - Prof. Golam M. Newaz
DTSTART:20150227T160000Z
DTEND:20150227T170000Z
UID:TALK57056@talks.cam.ac.uk
CONTACT:Anna Walczyk
DESCRIPTION:Nanopatterning can be a strategy to improve biocompatibility o
 f neural devices to modulate  neural cells and reduce astrogliosis. Two di
 fferent microelectrode materials\, poly (methyl methacrylate)\, PMMA and s
 apphire  are studied from the perspective of understanding cell-material i
 nteraction\; in the former case to avoid astrocyte reactivity and in the l
 atter case to promote neuronal cell attachment. The nanopatterning in thes
 e materials were achieved using nanoimprint lithography or hot embossing f
 or PMMA and via photolithography\, reactive sputtering and metal lift off 
 for the case of sapphire with deposited iridium oxide thin film. Results f
 rom our investigation confirm that certain nanotopograhy features can be e
 ffective in these materials to improve their functionality.  Cell-material
  interactions and biocompatibility of these materials are also addressed u
 sing controlled experiments and statistical results.
LOCATION: Cambridge University Engineering Department\, Lecture Room 6
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