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SUMMARY:Prostacyclin and nitric oxide in vascular biology - Sir Salvador M
 oncada
DTSTART:20150310T200000Z
DTEND:20150310T211500Z
UID:TALK57330@talks.cam.ac.uk
CONTACT:Adam
DESCRIPTION:Sir Salvador Moncada has made monumental contributions to phar
 macology and medicine. He determined the mechanism of action of aspirin-li
 ke drugs and led the discovery of the enzyme thromboxane synthase and the 
 vasodilator prostacyclin\, thus laying the foundation for use of aspirin t
 o prevent heart attack and stroke. He identified nitric oxide as a biologi
 cal mediator and established its significance in the cardiovascular system
  and nervous system. As Director of Research at the Wellcome Research Labo
 ratories\, he oversaw the discovery and development of many drugs now wide
 ly used\, including lamotrigine (an anti-epileptic)\, atovaquone (an anti-
 malarial) and zomig (for migraine headaches)\, and initiated the work that
  resulted in the development of lapatinib for the treatment of breast canc
 er. Currently the Director of the Institute of Cancer Sciences at the Univ
 ersity of Manchester and previously the Director of the UCL Wolfson Instit
 ute\, Sir Salvador was elected Fellow of the Royal Society in 1988. In ano
 ther chapter of an extraordinary career\, he will discuss his most recent 
 work in cell metabolism\, which has led to the finding of the molecular me
 chanism that coordinates cell proliferation with the provision of metaboli
 c substrates required for this process.\n\nEveryone is welcome. Free for m
 embers\, £2 on the door for non-members. Followed by refreshments (that m
 eans smoothies\, cheese and grapes!).
LOCATION:Department of Pharmacology Lecture Theatre\, Tennis Court Road
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