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SUMMARY:Understanding and overcoming drug resistance in tuberculosis - Ull
 a Lang
DTSTART:20150224T203000Z
DTEND:20150224T210000Z
UID:TALK57333@talks.cam.ac.uk
CONTACT:Paulina Rowicka
DESCRIPTION:A third of the world population is thought to be infected with
  Mycobacterium tuberculosis (Mtb)\, the causative agent of tuberculosis (T
 B). The World Health Organization estimates\, that in 2013\, about 9 milli
 on people developed the disease and 1.5 million people have died from it\,
  making TB the biggest infectious killer after HIV.Not many antibiotics ar
 e available to treat TB\, but the disease's treatment is now further imped
 ed by the emergence of multi-drug resistant bacterial strains. Unlike othe
 r bacteria\, Mtb cannot transfer resistances from one strain to another. T
 herefor\, the rate of antibiotic resistance in Mtb is directly determined 
 by the bacterium's intrinsic mutation rate. In order to understand how mut
 ations in the bacterial DNA are being generated\, we have to investigate h
 ow DNA is being copied during cell division. This process called DNA repli
 cation has not been studied so far in Mtb.\n\nIn this talk\, I will presen
 t new data from our lab showing that Mycobacterium tuberculosis copies its
  DNA differently from previously studied model organisms. Further\, we hav
 e found a way to disrupt this process\, which in the future could pose an 
 attractive therapeutic option for treatment of drug-resistant tuberculosis
 .\n
LOCATION:Senior Parlour\, Gonville &amp\; Caius College
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