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SUMMARY:Slow dynamics in self-assembly and protein folding - Rob Jack\, Un
 iversity of Bath
DTSTART:20150304T141500Z
DTEND:20150304T151500Z
UID:TALK57370@talks.cam.ac.uk
CONTACT:Lucy Colwell
DESCRIPTION:Self-assembly and protein-folding are examples of dynamical pr
 ocesses in which systems transform into ordered states that minimise their
  free energy.  The time scales associated with these processes vary over a
  wide range: in particular\, assembly or folding may be slow for a number 
 of different reasons.  Here\, we concentrate on slow dynamics that comes f
 rom kinetic trapping in metastable states.  In self-assembly\, we discuss 
 a set of kinetic factors that are essential in designing systems that will
  assemble effectively [1].  In protein-folding\, we show how a novel metho
 d based on biased ensembles of trajectories can identify metastable states
  from large computational data sets.  For several model proteins\, the met
 hod identifies  metastable states that are rich in beta-sheet structure [2
 ]: we discuss possible connections with the formation of amyloid fibrils.\
 n\n[1] S Whitelam and RL Jack\, arXiv:1407.2505\, to appear in Ann Rev Phy
 s Chem.\n[2] JK Weber\, RL Jack\, CR Schwantes and VS Pande\, Biophys J 10
 7\, 974 (2014)\n
LOCATION:Department of Chemistry\, Cambridge\, Pfizer lecture theatre
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