BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Chromatin unloading of the replicative DNA helicase during replica
 tion and repair - Johannes Walter
DTSTART:20150408T151500Z
DTEND:20150408T161500Z
UID:TALK57542@talks.cam.ac.uk
CONTACT:Scientific Meetings Co-ordinator
DESCRIPTION:Researchers studying eukaryotic DNA replication have made extr
 aordinary progress in understanding how the replicative DNA helicase (the 
 ‘CMG’ complex) is recruited to origins in G1\, how it is activated in 
 S phase\, how it unwinds DNA at the fork\, and how its de novo loading in 
 S phase is restricted to prevent re-replication.  By comparison\, we know 
 almost nothing about what happens when replisomes from adjacent origins me
 et\, including the mechanism of CMG unloading.  I will describe a cell-fre
 e system from Xenopus eggs that supports synchronous and site-specific rep
 lication termination\, and what we have learned about CMG unloading using 
 this approach.  I will compare and contrast CMG unloading during terminati
 on with its unloading during the repair of DNA interstrand cross-links.  O
 ur work suggests that the removal of CMG from chromosomes is an active and
  essential process that is carefully regulated to preserve genome integrit
 y.\n
LOCATION:Max Perutz Lecture Theatre\, Medical Research Council (MRC) (MRC 
 Laboratory of Molecular Biol
END:VEVENT
END:VCALENDAR