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SUMMARY:Genome-wide transcriptional control of blood cell type identity - 
 Felicia Ng\, Cambridge Institute for Medical Research
DTSTART:20150126T100000Z
DTEND:20150126T110000Z
UID:TALK57545@talks.cam.ac.uk
CONTACT:Microsoft Research Cambridge Talks Admins
DESCRIPTION:Transcription factors (TFs) have long been recognised as impor
 tant regulators of blood cell type identity. Despite advances in the gener
 ation of TF binding maps by ChIP-seq\, not much is known about the genome-
 wide impact of TF binding in driving transcriptional programs of multiple 
 cell types. In particular\, the rules that govern functional TF binding re
 main unclear and much remains to be learned about the mechanisms of combin
 atorial TF interactions\, including to what extent constrained spacing and
  orientation of interacting TFs are critical for regulatory element activi
 ty and cell type-specific gene regulation. A more comprehensive understand
 ing of the molecular mechanisms of transcription\, however\, is recognized
  to have broad implications for cellular reprogramming and medicine. Using
  genomics technology\, genome sequence analysis and statistical modelling\
 , this study provided greater insight into the role of transcription facto
 rs in establishing and maintaining distinct cell-type identity during the 
 process of blood cell maturation. In-depth analysis demonstrated that shar
 ed TFs actively participate in the transcriptional programmes of distinct 
 cell types and TFs preferentially bind with constrained spacing.
LOCATION:Auditorium\, Microsoft Research Ltd\, 21 Station Road\, Cambridge
 \, CB1 2FB
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