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SUMMARY:Local Transcriptomes and proteomes in neurons - Erin Schuman. Max 
 Planck Institute for Brain Research
DTSTART:20150302T163000Z
DTEND:20150302T180000Z
UID:TALK57546@talks.cam.ac.uk
CONTACT:P.H. Marchington
DESCRIPTION:Cajigas\, I.J.\, Tushev\, G.\, Will\, T.J.\, tom Dieck\, S.\, 
 Fuerst\, N.\, & Schuman. E.M.\n2012. The Local Transcriptome in the Synapt
 ic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging.  DOI 
 10.1016/j.neuron.2012.02.036\n\nAbstract. Nature Review Neuroscience 2013.
  Doi:10.1038/nrn3546\nProteostasis in complex dendrites.\nHanus\, C. & Sch
 uman\, E.M. Like all cells\, neurons are made of proteins that have charac
 teristic synthesis and degradation profiles. Unlike other cells\, however\
 , neurons have a unique multipolar architecture that makes ~10\,000 synapt
 ic contacts with other neurons. Both the stability and modifiability of th
 e neuronal proteome are crucial for its information-processing\, storage a
 nd plastic properties. The cell biological mechanisms that synthesize\, mo
 dify\, deliver and degrade dendritic and synaptic proteins are not well un
 derstood but appear to reflect unique solutions adapted to the particular 
 morphology of neurons.\n
LOCATION:The Hodgkin Huxley Seminar Room\, Department of Physiology Develo
 pment and Neuroscience
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