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SUMMARY:Computational Neuroscience Journal Club - Sina Tootoonian ( CBL\, 
 Engineering\, U. Cambridge)
DTSTART:20150127T160000Z
DTEND:20150127T170000Z
UID:TALK57559@talks.cam.ac.uk
CONTACT:Guillaume Hennequin
DESCRIPTION:We will cover: \n\nSynaptic and circuit mechanisms promoting b
 roadband transmission of olfactory stimulus dynamics\n\nKatherine I Nagel\
 , Elizabeth J Hong and Rachel I Wilson\; Nature Neuroscience (2015)\n\nhtt
 p://www.nature.com/neuro/journal/v18/n1/full/nn.3895.html\n\nSensory stimu
 li fluctuate on many timescales. However\, short-term plasticity causes sy
 napses to act as temporal filters\, limiting the range of frequencies that
  they can transmit. How synapses in vivo might transmit a range of frequen
 cies in spite of short-term plasticity is poorly understood. The first syn
 apse in the Drosophila olfactory system exhibits short-term depression\, b
 ut can transmit broadband signals. Here we describe two mechanisms that br
 oaden the frequency characteristics of this synapse. First\, two distinct 
 excitatory postsynaptic currents transmit signals on different timescales.
  Second\, presynaptic inhibition dynamically updates synaptic properties t
 o promote accurate transmission of signals across a wide range of frequenc
 ies. Inhibition is transient\, but grows slowly\, and simulations reveal t
 hat these two features of inhibition promote broadband synaptic transmissi
 on. Dynamic inhibition is often thought to restrict the temporal patterns 
 that a neuron responds to\, but our results illustrate a different idea: i
 nhibition can expand the bandwidth of neural coding.
LOCATION:Cambridge University Engineering Department\, CBL\, BE-438 (http:
 //learning.eng.cam.ac.uk/Public/Directions)
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