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SUMMARY:Evolution of Bacterial Genomic Networks - Dr Martin Lercher\, Univ
 ersity of Bath &amp\; EMBL
DTSTART:20061023T123000Z
DTEND:20061023T133000Z
UID:TALK5766@talks.cam.ac.uk
CONTACT:Nicholas Luscombe
DESCRIPTION:Two major forces by which bacterial populations adapt are gain
  and loss of genes. In order to understand these processes\, it is necessa
 ry to analyse them in a systemic context. We chose E. coli as our model sy
 stem\, as it is one of the best studied cellular systems\, and because of 
 the availability of experimentally verified simulation methods for its met
 abolic network. How and why did E. coli's metabolic network change in the 
 course of evolution? What is the contribution of horizontal transfer of ge
 nes between unrelated strains? What forces affect the fixation and integra
 tion of new genes into their host? Can we make quantitative predictions ab
 out the course of reductive evolution in endosymbionts? These are some of 
 the questions that I will answer during my talk.
LOCATION:Shared facilities C209/210
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