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SUMMARY:Adjusting accordingly: prefrontal areas updating valuations for ob
 jects and actions - Dr Betsy Murray\, Chief\, Laboratory of Neuropsycholog
 y\, National Institute of Mental Health\, Bethesda\, MD
DTSTART:20150515T140000Z
DTEND:20150515T153000Z
UID:TALK57810@talks.cam.ac.uk
CONTACT:Louise White
DESCRIPTION:Betsy Murray\, Ph.D.\n\nThe goal of our research program is to
  understand the mechanisms of the primate frontal lobe and the amygdala in
  reward processing and emotion at a causal level. Specifically\, we aim to
  understand the interactions among brain regions that play a necessary rol
 e in updating representations of value (i.e.\, valuations) of expected and
  received rewards based on current biological needs\, and how these valuat
 ions influence decisions.  Notably\, the brain regions involved in valuati
 on functions in macaques are the same regions thought to be dysfunctional 
 in major depressive disorder (MDD)\, and we have proposed that the valuati
 on functions of orbital and medial frontal cortex in macaques may offer in
 sights into the mechanisms underlying MDD.\n\nRudebeck PH\, and Murray EA 
 (2014) The orbitofrontal oracle: cortical mechanisms for the prediction an
 d evaluation of specific behavioral outcomes. Neuron\, 84: 1143-1156. Revi
 ew\nRudebeck PH\, Mitz AR\, Chacko RV\, and Murray EA (2014) Effects of am
 ygdala lesions on reward-value coding in orbital and medial prefrontal cor
 tex. Neuron\, 80: 1519-1531.\nRhodes SEV\, and Murray EA (2013) Differenti
 al effects of amygdala\, orbital prefrontal cortex and prelimbic cortex le
 sions on goal-directed behavior in rhesus macaques. Journal of Neuroscienc
 e\, 33: 3380-3389.\nRudebeck PH\, Saunders RC\, Prescott AT\, Chau LS\, an
 d Murray EA (2013) Prefrontal mechanisms of behavioral flexibility\, emoti
 on regulation\, and value updating. Nature Neuroscience\, 16: 1140-1145.\n
 Murray EA\, Wise SP\, and Drevets WC (2011) Localization of dysfunction in
  major depressive disorder: prefrontal cortex and amygdala. Biological Psy
 chiatry\, 69: e43-54\,  doi:10.1016/j.biopsych.2010.09.041.\n
LOCATION:Ground Floor Lecture Theatre\, Department of Psychology
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