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SUMMARY:Engineering complex metabolic feedback in Escherichia coli - Dr Fe
 lix Moser\, MIT Bioengineering &amp\; Broad Institute
DTSTART:20150210T160000Z
DTEND:20150210T173000Z
UID:TALK57981@talks.cam.ac.uk
CONTACT:Helen Scott
DESCRIPTION:Synthetic  genetic  circuits  have  become  increasingly  comp
 lex and easier  to  design and  build.  But  what  are  they  good  for? W
 e present  a  prototype  application  for  a  synthetic  genetic  circuit 
  that  assesses  and  responds  to  conditions  that  lead  to acetate pro
 duction in Escherichia coli\, a wasteful process in industrial  fermentati
 on. The circuit uses sensors  for acetate\, oxygen\, and glycolytic flux (
 factors relevant to acetate production) to gather information about the ce
 llular environment\, integrates these signals using orthogonal sets of tra
 nscription factors\, and then expresses response molecules that reduce ace
 tate production. Such a system offers the advantage of programmable feedba
 ck control of metabolism at single-cell resolution and serves to demonstra
 te the value proposition of synthetic genetic circuits for metabolic engin
 eering and process control.\n\nMoser\, F.\, Broers\, N.\, Hartmans\, S.\, 
 Tamsir\, A.\, Kerkman\, R.\, Roubos\, J.A.\, Bovenberg\, R.\, & C.A. Voigt
  (2012). Genetic Circuit Performance under Conditions Relevant for Industr
 ial Bioreactors. ACS Synth. Biol.\, 1(11): 555-564.\n\nMoser\, F.\, Horwit
 z\, A.\, Chen\, J.\, Lim\, W.A.\, & C.A. Voigt (2013). A genetic sensor fo
 r strong methylating compounds. ACS Synthetic Biology\, 2(10): 614-614.
LOCATION:Large Lecture Theatre\, Department of Plant Sciences
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