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SUMMARY:Neuroimmune interactions in early development and the biological e
 mbedding of health disparities - Professor Staci Bilbo\, Duke Institute fo
 r Brain Sciences\, Duke University\, USA
DTSTART:20150423T150000Z
DTEND:20150423T160000Z
UID:TALK58046@talks.cam.ac.uk
CONTACT:16026
DESCRIPTION:The study of neural-glial interactions within the brain is in 
 its infancy.  However\, there is mounting evidence that microglia and ast
 rocytes\, the primary immunocompetent cells of the CNS\, are involved in e
 very major aspect of brain development and function\, including neurogenes
 is and migration\, synaptic formation and pruning\, and phagocytosis of ap
 optotic debris.  Many cytokines and chemokines (e.g.\, interleukin [IL]-1
 β and CCL2\, respectively) are produced by glia at much higher baseline l
 evels in the developing brain compared to the adult brain\, although this 
 time course depends highly on brain region and sex. These collective data 
 have led us to hypothesize that early development \nrepresents a sensitive
  period for immune perturbation and thus long-term alterations in neural f
 unction\, because the immune system is so active within the brain at this 
 time. Indeed\, evidence from both animal and human studies implicates the 
 immune system in a number of disorders with known or suspected development
 al origins.  This talk will focus on the evidence that diverse challenges
  (e.g.\, infection\, toxins\, maternal stress) during distinct stages of d
 evelopment act as a vulnerability factor for later-life alterations in cen
 tral immune signaling\, and marked changes in behavior throughout the rema
 inder of the lifespan\, with a focus on the hypothesis that long-term chan
 ges in microglial cell function may underlie such vulnerability.\n\nhttp:/
 /dibs.duke.edu/research/profiles/47-staci-bilbo\nhttp://www.neuro.duke.edu
 /training-faculty\n
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\, Downing Site
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