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SUMMARY:Epigenetic inheritance and reprogramming in the mammalian germline
  - Jamie Hackett\, Gurdon Institute\, Wellcome Trust
DTSTART:20150310T143000Z
DTEND:20150310T153000Z
UID:TALK58074@talks.cam.ac.uk
CONTACT:Dr. Monica Vega-Hernandez
DESCRIPTION:Epigenetic mechanisms act to define and restrict cellular iden
 tity. In mammals\, primordial germ cells (PGC)\, the precursors to sperm a
 nd oocytes\, undergo unprecedented reprogramming including global erasure 
 of DNA methylation and genomic imprints. This process resets the epigenome
  to enable the acquisition of totipotency – the capacity to form all cel
 l types – in the zygote. We have been investigating the mechanism that d
 rives comprehensive epigenome resetting in PGCs and find a key role for TE
 T-mediated 5-hydroxymethylation. We also find rare loci that escape from e
 pigenetic reprogramming in PGCs. The epigenetic states at these genomic si
 tes may represent a mechanism for transgenerational epigenetic inheritance
 \, which may be sensitive to environmental perturbations
LOCATION:4th floor Cockcroft building\, New Museums Site\, Pembroke Street
 \, Cambridge CB2 3QG
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