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SUMMARY:Inhibitory activities of short linear motifs underlie Hox interact
 ome specificity in vivo. - Dr Samir Merabet\, IGFL France
DTSTART:20150611T133000Z
DTEND:20150611T143000Z
UID:TALK58081@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Hox proteins are well-established developmental regulators tha
 t coordinate cell fate and morphogenesis throughout embryogenesis. In cont
 rast\, our knowledge of their specific molecular modes of action is limite
 d to the interaction with few cofactors. Here we show that Hox proteins ar
 e able to interact with a wide range of transcription factors in the live 
 Drosophila embryo. In this context\, specificity relies on a versatile usa
 ge of conserved short linear motifs (SLiMs)\, which\, surprisingly\, often
  restrains the interaction potential of Hox proteins. This novel buffering
  activity of SLiMs was observed in different tissues and found in Hox prot
 eins from cnidarian to mouse  species. Although these interactions remain 
 to be analysed in the context of endogenous Hox regulatory activities\, ou
 r observations challenge the traditional\nrole assigned to SLiMs and provi
 de an alternative concept to explain how Hox interactome specificity could
  be achieved during the embryonic development.\n
LOCATION:Part II Room\, Department of Genetics
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