BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Genetic screening of the human kinome identifies a cellular signal
 ling network predictive of brain atrophy in Alzheimer's disease &amp\; Cir
 cadian abnormality in Alzheimer's disease: insights from animal models - B
 ecky Inkster (Dept Psychiatry) &amp\; Ko-Fan Chen (Dept Genetics)
DTSTART:20150415T173000Z
DTEND:20150415T190000Z
UID:TALK58143@talks.cam.ac.uk
CONTACT:YS
DESCRIPTION:“Genetic screening of the human kinome identifies a cellular
  signalling network predictive of brain atrophy in Alzheimer's disease” 
 (Becky Inkster)\nSearching for gene variants that influence brain atrophy 
 in Alzheimer's disease is highly warranted\; however\, conventional genome
 -wide approaches have limited statistical power and fail to incorporate in
 formation about intrinsic biological relationships. The speaker will prese
 nt new unpublished findings of a genetic network of kinases that putativel
 y represent a set of functionally diverse genetic factors that relate to\,
  and possibly predict\, AD neurodegeneration.\n\n“Circadian abnormality 
 in Alzheimer's disease: insights from animal models” (Ko-Fan Chen)\nCirc
 adian abnormality\, such as sleep fragmentation and disruption in rest/act
 ivity cycle\, has been observed in various neurodegenerative disorders inc
 luding Alzheimer’s disease (AD). The speaker will summarise circadian be
 havioural characteristics in AD and highlight the technical advances in me
 asuring sleep and circadian behaviour in the\nrelated murine and fly model
 s.\n\n\n
LOCATION:Gurdon Institute Tea Room
END:VEVENT
END:VCALENDAR