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SUMMARY:New Roles for Lysine Methylation Signaling in Epigenetic and Cance
 r Regulation - Or Gozani\, Stanford University\, California
DTSTART:20150521T120000Z
DTEND:20150521T130000Z
UID:TALK58386@talks.cam.ac.uk
CONTACT:Neil Bennett
DESCRIPTION: The main focus of the Gozani laboratory is to understand the 
 molecular mechanisms by which protein lysine methylation regulates chromat
 in biology\, epigenetics\, and cellular signaling\, and how disruption in 
 these mechanisms contribute to cancer and other diseases. We study how lys
 ine methylation events on histone and non-histone proteins are generated\,
  sensed\, and transduced\, and how these chemical marks integrate with oth
 er modification and cellular signaling networks to govern diverse function
 s. We previously identified the PHD finger and the BAH domain as methyl ly
 sine-binding “reader” domains and provided evidence that disrupting th
 e read-out of histone modifications can cause inherited human diseases. Cu
 rrent research efforts are aimed at discovery and characterization of new 
 methyl-sensitive reader domains functioning in both chromatin and non-chro
 matin pathways. Another major focus of the lab is to develop and apply pro
 teomic strategies to uncover the catalytic and biological functions of the
  many orphan or poorly characterized protein lysine methyltransferases pre
 sent in the human genome. I will discuss our most recent work in these are
 as with a focus on two enzymes implicated in tumorigenesis.
LOCATION:Cancer Research UK Cambridge Research Institute\, Lecture Theatre
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