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SUMMARY:Reconstructing the evolutionary history of tumours - Prof Quaid Mo
 rris (Toronto)
DTSTART:20150413T150000Z
DTEND:20150413T160000Z
UID:TALK58437@talks.cam.ac.uk
CONTACT:Florian Markowetz
DESCRIPTION:Tumours contain genetically related subpopulations that can di
 ffer in their metastatic potential and response to treatment. This heterog
 eneity also provides a basis to reconstruct the evolutionary history of in
 dividual tumours thereby providing insights into how cancers develop. I wi
 ll discuss our work over the past few years on designing algorithms to rec
 onstruct tumour phylogenies by deconvolving data from cancer genome sequen
 cing efforts.\n\nOften the first step in characterizing tumour subpopulati
 ons is clustering somatic mutations (both point and structural) according 
 to their inferred population frequencies. This is only a partial character
 ization: these clusters correspond to cell lineage and these lineages can 
 include multiple subclonal populations. Determining whether or not differe
 nt groups of mutations are present in the same subpopulations requires rec
 onstructing the tumour phylogeny. We have developed a series of algorithms
  (PhyloSub\, PhyloWGS\, PhyloSpan) that use Bayesian inference in non-para
 metric models to do this. These methods explicitly represent uncertainty t
 hereby distinguishing ambiguous and unambiguous portions of the reconstruc
 tion. We are currently applying these methods to more than 2\,000 tumors a
 s part of the ICGC pan-cancer whole genome analysis effort.\n\n\n
LOCATION:CRUK CI Room 215
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