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SUMMARY:Interrogating the Architecture of Cancer Genomes - Dr Peter Campbe
 ll\,  Head of Cancer Genome Project\, Wellcome Trust Sanger Institute.
DTSTART:20150623T110000Z
DTEND:20150623T120000Z
UID:TALK58494@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:ABSTRACT:\nCancer is driven by mutation. Using massively paral
 lel sequencing technology\, we can now sequence the entire genome of cance
 r samples\, allowing the generation of comprehensive catalogues of somatic
  mutations of all classes. Bespoke algorithms have been developed to ident
 ify somatically acquired point mutations\, copy number changes and genomic
  rearrangements\, which require extensive validation by confirmatory testi
 ng. The findings from our first handful of genomes illustrate the potentia
 l for next-generation sequencing to provide unprecedented insights into mu
 tational processes\, cellular repair pathways and gene networks associated
  with cancer development. I will also review possible applications of thes
 e technologies in a diagnostic and clinical setting\, and the potential ro
 utes for translation.\n
LOCATION:CRUK CI Lecture Theatre
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