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SUMMARY:Cell-size control and homeostasis at the single-cell level - Profe
 ssor Suckjoon Jun\, UCSD Physics and Molecular Biology
DTSTART:20150317T160000Z
DTEND:20150317T170000Z
UID:TALK58506@talks.cam.ac.uk
CONTACT:Dr Eileen Nugent
DESCRIPTION:How cells control their size is one of the oldest\, unsolved p
 roblems in biology. Two extreme textbook models state that the cell senses
  its absolute size (thus ’sizer’) or uses an internal ’timer’ to t
 rigger cell division. I will present an unexpectedly simple and general ce
 ll-size control and homeostasis principle for bacteria. This ‘adder’ p
 rinciple overturns the sizer and timer models and is shared by both Gram-n
 egative E. coli and Gram-positive B. subtilis (which are a billion years d
 ivergent). Furthermore\, the adder principle explains not only the populat
 ion-level results quantitatively\, but also the origin\, hierarchy and int
 er-relationship of the variability of basic cellular processes of growth a
 nd cell division of individual cells.
LOCATION:Ryle Seminar Room no930\, Rutherford Building\, Cavendish Laborat
 ory
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