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SUMMARY:Back to basics: fundamentals forces in protein structure\, design 
 &amp\; interactions - Dek Woolfson\, University of Bristol
DTSTART:20150527T131500Z
DTEND:20150527T141500Z
UID:TALK58739@talks.cam.ac.uk
CONTACT:Lucy Colwell
DESCRIPTION:Despite considerable effort\, the fundamental forces that unde
 rpin protein folding\, form and function are not fully understood.  Using 
 a combination of bioinformatics\, computational biochemistry\, and peptide
  design\, synthesis and characterisation\, my group is exploring some of t
 he non-covalent forces at play in protein folding and assembly\, and in pr
 otein-small molecule interactions.  This talk will describe some of our re
 cent work on: electrostatic and n-to-π star interactions in α-helices [1
 \,2]\; how hydrophobic and van der Waals’ interactions can be designed t
 o direct the assembly of entirely new α-helical barrel structures [3]\; a
 nd how natural proteins bind and distinguish between different carbohydrat
 e moieties through electrostatic complementary and CH-π star interactions
  [4].  Time allowing\, I will also describe how we are creating standard p
 eptide components to assemble new supramolecular objects [5].\n\n1.	n-to-
 π* Interactions in proteins\nGJ Bartlett\, A Choudhary\, RT Raines\, and 
 DN Woolfson\nNature Chemical Biology 6\, 615-620 (2010)\n\n2.	Local and ma
 croscopic electrostatic interactions in single α−helices\nEG Baker\, GJ
  Bartlett\, MP Crump\, RB Sessions\, N Linden\, CFJ Faul\, and DN Woolfson
 \nNature Chemical Biology 11\, 221-8 (2015)\n\n3.	Computational design of 
 water-soluble α−helical barrels.\nAR Thomson\, CW Wood\, AJ Burton\, GJ
  Bartlett\, RB Sessions\, RL Brady\, and DN Woolfson\nScience 346\, 485-48
 8 (2014)\n\n4.	An electronic component to CH-π interactions in protein-ca
 rbohydrate complexes\nKL Hudson\, GL Bartlett\, RC Diehl\, J Agirre\, T Ga
 llagher\, LL Kiessling\, and DN Woolfson\nSubmitted\n\n5.	Self-assembling 
 cages from coiled-coil peptide modules\nJM Fletcher\, RL Harniman\, FRH Ba
 rnes\, AL Boyle\, A Collins\, J Mantell\, TH Sharp\, M Antognozzi\, PJ Boo
 th\, N Linden\, MJ Miles\, RB Sessions\, P Verkade\, and DN Woolfson\nScie
 nce 340\, 595-599 (2013)	\n\n\n
LOCATION:Todd Hamied Room\, Dept. of Chemistry
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