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SUMMARY:&quot\;Synergistic effect of radiotherapy and cis-platinum chemoth
 erapy delivered via gold nanoparticles in glioblastoma multiforme&quot\; -
  Sara Piccirillo and  Alexandra Vaideanu\, Nanoscience Centre\, Department
  of Engineering\, University of Cambridge
DTSTART:20150908T110000Z
DTEND:20150908T120000Z
UID:TALK58754@talks.cam.ac.uk
CONTACT:Mala Jayasundera
DESCRIPTION:Alexandra G. Vaideanua\, Sonali Setuaa\, Myriam Ouberaia\, Col
 in Wattsb\, Mark Wellanda\n\naNanoscience Centre\, Department of Engineeri
 ng\, University of Cambridge\, Cambridge\nCB3 0FF\, UK\; e-mail: mew10@cam
 .ac.uk\nbJohn van Geest Centre for Brain Repair\, Department of Clinical N
 eurosciences\,\nUniversity of Cambridge\, Forvie Site\, Robinson Way\, Cam
 bridge CB2 0PY\, UK\n\nGlioblastoma multiforme is one of the most aggressi
 ve types of cancer.  Despite current therapies and standard care patients 
 survive on average 14 months after diagnosis. The aim of our work is to de
 monstrate the efficacy of a multimodal nanotechnology based on gold nanopa
 rticles in killing glioblastoma cells in human tissue derived cell lines i
 n vitro. We have showed previously1 the synergistic effect of chemotherapy
  and radiotherapy in a construct based on spherical gold nanoparticles coa
 ted with mercaptoundecanoic acid (MUA) to which we attached cis-platinum d
 rug. The increased radiosensitization due to the gold atoms and the delive
 ry of cis-platinum to the tumour cells resulted in a decreasing trend in t
 he recurrence and survival of the cell lines tested. To further improve th
 e technology we have used a modified construct in which we replace the MUA
  coating with a polyethyleneglycol (PEG) linker. This improved the uptake 
 of nanoparticles via an enhanced permeability retention effect facilitated
  by the leaky tumour vasculature and as a consequence of reduced interacti
 on of PEG shielded carriers with opsonins. Further strategies in maximizin
 g the efficiency of the system include the attachment of a tumour homing p
 eptide\, GRGDR\, to specifically target receptors at the surface of gliobl
 astoma cells. The end goal of this work is to validate these findings via 
 in vivo mouse models and to ultimately submit this technology for clinical
  trials. \n\n1. Setua\, S.\, Ouberai\, M.\, Piccirillo\, S. G.\, Watts\, C
 . & Welland\, M. Cisplatin-tethered gold nanospheres for multimodal chemo-
 radiotherapy of glioblastoma. Nanoscale 6\, 10865–10873 (2014)\n\n
LOCATION:CRUK CI Lecture Theatre
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